Caspases Downstream of DIAP1 in Drosophila S2 Cells: In What Order are They Activated and What Role Does the Proteasome Play in Their Degradation?
نویسندگان
چکیده
Specific Aims SA1. Determine which of the seven identified Drosophila caspase genes are expressed in Drosophila melanogaster S2 cells. SA2. Identify which of the expressed caspases are downstream of DIAP1 in the apoptosis pathway of S2 cells. SA3. Explore the order in which expressed initiator and effector caspases are activated and study the function of proteasomal degradation in regulating the initiator caspase DRONC.
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